(A74) Reducing the Potential for Tourniquet Associated Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb
BACKGROUND Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage to skeletal muscle. The purposes of this study were 1) to assess the histological findings of gastrocnemius muscle (GC) and tibialis anterior muscle (TA) in I/R injury model mice, 2) to histologically analyze whether a single pretreatment of edaravone inhibits I/R injury...
متن کاملProtective Effect of Edaravone for Tourniquet-Induced Ischemia-Reperfusion Injury on Skeletal Muscle in Murine Hindlimb
in Murine Hindlimb Hori K, +Tsujii M, Iino T, Satonaka H, Uemura T, Nishimura A, Akeda K, Hasegawa M, Sudo A Department of Orthopaedic Surgery, Graduate School of Medicine Mie University [email protected] Introduction Ischemia-reperfusion (I/R) injury refers to damage tissue caused when blood returns to the tissue after a period of ischemia. Reperfusion triggers a cascade of acute i...
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It seems surprising that more than five decades of intense biochemical and molecular research on a leading cause of death and disability globally—ischaemic myocardial injury/myocardial infarction—and the spending of huge sums of money have achieved relatively little in the prevention of cell death secondary to ischaemia. The greatest progress has been made in methods to mechanically or chemical...
متن کاملThe effect of recombinant human MG53 protein on tourniquet- induced ischemia reperfusion injury in rat muscle
Introduction—Skeletal muscle ischemia reperfusion injury (I-R) is a complex injury process that includes damage to the sarcolemmal membrane, contributing to necrosis and apoptosis. MG53, a muscle-specific TRIM family protein, has been shown to be essential for regulating membrane repair and has been shown to be protective against cardiac I-R and various forms of skeletal muscle injury. The purp...
متن کاملInfluence of fiber-type composition on recovery from tourniquet-induced skeletal muscle ischemia-reperfusion injury.
This study was designed to determine if previously reported differences in the functional impairment of muscles composed of predominantly different fiber types occurs following extended periods of ischemia. We hypothesized that the soleus (Sol) muscle, a predominantly slow-twitch muscle, would be less vulnerable to tourniquet-induced ischemia-reperfusion than the plantaris (Plant), a predominan...
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ژورنال
عنوان ژورنال: Prehospital and Disaster Medicine
سال: 2011
ISSN: 1049-023X,1945-1938
DOI: 10.1017/s1049023x11000811